Amylyx is starting to recruit for a phase III clinical trial

| By Sabrina Da Rocha
Categories: News, Research News

For PSP Patients and Care Partners: Amylyx is starting to recruit for a phase III clinical trial to evaluate the clinical safety, tolerability, and efficacy of a potential treatment for adults with PSP. We encourage you to learn more about this effort. Below, you will find more information on the trial and a link to …

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Amylyx Pharmaceuticals Announces First Participant Dosed in the Global Phase 3 ORION Study of AMX0035 in Progressive Supranuclear Palsy (PSP)

| By Sabrina Da Rocha
Categories: News, Research News
– Largest ever PSP clinical trial will evaluate the efficacy and safety of AMX0035 in adults with PSP compared to placebo – Trial to enroll approximately 600 participants across the U.S., Canada, Europe, and Japan   CAMBRIDGE, Mass.–(BUSINESS WIRE)– Amylyx Pharmaceuticals, Inc. (NASDAQ: AMLX) (“Amylyx” or the “Company”) today announced that the first participant has …

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CurePSP funds four new grants to advance treatment of prime of life neurodegeneration

| By Sabrina Da Rocha
Categories: News, Research News
  Studies at leading institutions may result in therapeutic approaches for PSP, CBD, FTD, and related diseases. NEW YORK, Sept. 10, 2021 /PRNewswire/ — CurePSP has awarded Venture Grants totaling $320,000 to scientists at Harvard Medical School, Columbia University, UT Southwestern Medical Center, and UCLA. The studies will investigate gene therapy, neuroprotective enzymes, activation of …

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CurePSP’s clinical guide to rare neurodegenerative conditions is published by leading neurology journal

| By Sabrina Da Rocha
Categories: News, Research News
Frontiers in Neurology today published a consensus statement on the best practices in the clinical management of progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS; the most common symptomatic manifestation of the disease called corticobasal degeneration or CBD), created under the auspices of CurePSP and in collaboration with directors and team members from CurePSP Centers …

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FAQ on FDA Approval of Aducanumab

| By Sabrina Da Rocha
Categories: News, Research News
  On June 7, 2021, the FDA approved aducanumab, a monoclonal antibody made by Biogen, for use in Alzheimer’s disease in the US.  Here’s a quick list of frequently asked questions and their answers as provided by Lawrence I. Golbe, MD, CurePSP’s Director of Clinical Affairs What does the FDA’s approval of aducanumab for Alzheimer’s mean for PSP and CBD, considering both …

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CurePSP awards three new Venture Grants for the study of PSP and CBD

| By Sabrina Da Rocha
Categories: News, Research News
Studies will focus on toxic protein in the brain and genetic factors CurePSP has awarded Venture Grants to three researchers studying tau protein pathology and genetic factors in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Each grant is for $100,000. Dr. Rohan de Silva of UCL Queen Square Institute of Neurology in London has …

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CurePSP and the Rainwater Charitable Foundation partner to support a collaborative biobanking platform for frontotemporal dementia research

| By Sabrina Da Rocha
Categories: News, Research News
Partnership will support efforts to enhance quantity and quality of neuropathologic FTD research worldwide The Rainwater Charitable Foundation and CurePSP today announced their partnership to support an initiative to establish a federated network of brain banks that will be enabled to allow increased access to tissue for researchers as they work toward bringing effective treatments …

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UCB pauses the development of bepranemab for progressive supranuclear palsy

| By Sabrina Da Rocha
Categories: News, Research News
A note from Kristophe Diaz, PhD, CurePSP Vice President- Scientific Affairs To our patients, caregivers, supporters, advocates, and volunteers: At CurePSP, one of our responsibilities is to stay closely connected to the leaders of the biotechnology and pharmaceutical sector.  This allows us, with the help of our medical and scientific advisors, to keep up with …

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Advisory on COVID-19 vaccines and PSP, CBD, and MSA from Lawrence I. Golbe, MD

| By Sabrina Da Rocha
Categories: News, Research News
Print CurePSP COVID-19 Vaccines Advisory Advisory on COVID-19 Vaccines From Lawrence I. Golbe, MD, Director of Clinical Affairs, CurePSP I am clinical director at CurePSP, a nonprofit based in New York City, dedicated to support of those suffering from PSP, CBD and MSA and their families and caregivers. This memo indicates that PSP, CBD or …

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CurePSP Partners With Rainwater to Support Pioneering Neurodegeneration Research

| By Sabrina Da Rocha
Categories: News, Research News
Study will use ‘miniature brains’ cultivated from stem cells to study protein mutations Tweet this NEW YORK–(BUSINESS WIRE)–CurePSP has awarded a $100,000 grant for a potentially breakthrough study that will employ 3D organoid models that have been shown to produce structures similar to those seen in the human brain to understand the effects of protein …

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Scientific American Article Cites Tau Protein as Linchpin to Finding Neurodegeneration Cure

| By Sabrina Da Rocha
Categories: Research News
In a recently published article, “Tau Shows Promise as Achilles’ Heel for Alzheimer’s and Similar Diseases,” the respected journal Scientific American reports that the recent emphasis on the understanding of the pathology of tau protein accumulation in the brain represents new hope of finding treatment and cure for many neurodegenerative diseases. Abnormal tau protein accumulation is …

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Biogen Ends Trial of Its Drug for PSP

| By Denise Forero
Categories: News, Research News
Our Letter to the PSP Community Regarding Biogen Trial Results By Lawrence I. Golbe, MD, Director of Scientific Affairs The pharmaceutical company Biogen announced today that the trial of its drug for PSP, gosuranemab, has failed to slow the progression of the disease.  The trial included a 12-month period during which some patients received gosuranemab, …

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AbbVie Ends Tau Antibody Study

| By Sabrina Da Rocha
Categories: News, Research News
AbbVie has ended the clinical trial of its intravenously administered antibody designed to slow the progression of PSP when it failed to show benefit.  The double-blind study started in 2017 and has enrolled 378 patients in eight countries.  The study was on track to end in early 2020, but an interim analysis showed no benefit …

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CurePSP Awards Seven New Research Grants

| By Sabrina Da Rocha
Categories: News, Research News
NEW YORK–(July 29, 2019)–CurePSP, the foundation for prime of life neurodegeneration, has awarded grants to scientific research into progressive supranuclear palsy (PSP) and related diseases totaling more than USD 200,000. The funding includes two Venture Grants totaling USD 190,000 and five student grants of USD 3,000 each. “Although PSP is rare, it is of great …

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CurePSP Names Dr. Lawrence I. Golbe, Eminent Clinician, as Head of Scientific Affairs

| By Denise Forero
Categories: News, Research News
He succeeds Dr. Alex Klein, who moves to UCB post in Brussels NEW YORK (February 20, 2019) – CurePSP, the foundation for prime of life neurodegeneration, has named Lawrence I. Golbe, MD, one of the world’s leading clinical experts in progressive supranuclear palsy (PSP) and related neurodegenerative conditions, as its Director – Scientific Affairs. He …

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Rush University Medical Center Caregiver Study

| By Sabrina Da Rocha
Categories: News, Research News
Have You Been a Caregiver for Someone with Parkinson’s Disease, PSP, MSA, CBD, or a related disorder? You have learned a lot by caring for your loved one with Parkinson’s Disease (PD), PSP, MSA, CBD, or a related disorder. Would you like to help other caregivers on their journey by sharing your experience? Rush University …

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CurePSP supports four new studies through its Venture Grants program

| By Sabrina Da Rocha
Categories: News, Research News
Research will study genetic factors and tau-protein pathologies in progressive supranuclear palsy (PSP) NEW YORK–(BUSINESS WIRE)— CurePSP, the foundation for prime of life neurodegeneration, has funded four grants at a total of more than $300,000 to investigators at universities in the U.S. and Germany for innovative studies in progressive supranuclear palsy (PSP). PSP is an …

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New Clinical Trial

| By Lucas Metherall
Categories: Research News
NEW CLINICAL RESEARCH TRIAL FOR PROGRESSIVE SUPRANUCLEAR PALSY (PSP) IS NOW RECRUITING   Progressive Supranuclear Palsy (PSP) is a neurodegenerative disease. In brain cells affected by PSP, there is an abnormal accumulation of a protein called tau. Tau protein forms “tangles” in the brain cells. It can spread outside the affected brain cell in the …

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CurePSP Teams Up With the Tau Consortium

| By Lucas Metherall
Categories: Research News
    CurePSP and the Rainwater Charitable Foundation Launch the Prime of Life Brain Initiative The initiative will support neurodegeneration research with goal of finding treatment and cure NEW YORK, April 10, 2018 – CurePSP and the Rainwater Charitable Foundation (RCF) today announced their landmark partnership in the Prime of Life Brain Initiative, an unprecedented …

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An Opportunity to Share Your Experience

| By Lucas Metherall
Categories: Research News
We have been informed of a research project by a company wishing to learn, in detail, the patient and carepartner journey. This information will inform potential drug developers’ clinical trial operations and processes, to make clinical trial attendance as suitable as possible to the patient and carepartner. The interview, among other things, will cover a …

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Currently Funded Research – CurePSP

| By Lucas Metherall
Categories: Research News
Developing Treatments for Swallowing and Communication Deficits in PSP Dr. Michelle S. Troche, Columbia University CurePSP is very excited to fund Dr. Troche’s research in an often overlooked area of care for PSP patients: swallowing and communication. Results of this study could have direct implications on how PSP patients are treated to improve their swallowing …

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Simple Walking Test May Help Make Difficult Diagnosis

| By Lucas Metherall
Categories: Research News
AMERICAN ACADEMY OF NEUROLOGY\ PUBLIC RELEASE: 21-FEB-2018 MINNEAPOLIS – There’s a cause of dementia that can sometimes be reversed, but it’s often not diagnosed because the symptoms are so similar to those of other disorders. Now researchers say a simple walking test may be able to accurately diagnose the disease, according to a study published the …

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New Sleep Pattern Clinical Trial for PSP Patients

| By Lucas Metherall
Categories: Research News
Study Currently Not Recruiting For more information, contact Dr. Christine Walsh at Christine.Walsh@ucsf.edu About the Study The goal of this study is to improve the quality of life of individuals with PSP by improving their sleep through a remote trial process. Research shows that individuals with PSP often have profound sleep disruption. Not only were these …

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Tau Pipeline Enabling Program (T-PEP)

| By Lucas Metherall
Categories: Research News
The Rainwater Foundation is proud to announce that the Tau Consortium has just launched a new matching grant program with The Alzheimer’s Association. It’s called the Tau Pipeline Enabling Program (T-PEP), and its goals is to accelerate the discovery of potential new therapies for tauopathies, including Alzheimer’s (AD), Frontotemporal Dementia (FTD), and Progressive Supranuclear Palsy …

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Announcement regarding a recent press release from Dthera Sciences

| By Lucas Metherall
Categories: Research News
Dthera Sciences recently announced its participation in a pilot program with CurePSP on Dthera’s ReminX digital therapeutic that is intended to reduce anxiety, anger, stress, and depression among PSP patients. Data that were reported were developed from a pilot study based on initial reports from 10 participants who are patients diagnosed with PSP. The study …

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Care Where It Counts: Understanding the Needs of People with PSP and Related Disorders

| By Lucas Metherall
Categories: Research News
      CurePSP is proud to support this survey by our friends at NYU Langone, and Rush University – Care Where it Counts: Understanding the Needs of People with PSP and Related Disorders. Goals People with Progressive Supranuclear Palsy and related disorders like Multiple System Atrophy and Corticobasal Syndrome may have trouble accessing the …

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Brain Food: Diet and Brain Health

| By Lucas Metherall
Categories: Research News
Brain Food: Can the foods you eat enhance brain health, or even help manage a neurologic condition? We spoke to the experts about popular diets and reviewed the evidence to find the answers. This article was first published by Marisa Cohen in Neurology Now, June/July 2017, Vol 13.   We eat for energy, for sustenance, …

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Anti-Tau Drugs for PSP Move into Phase II

| By Lucas Metherall
Categories: Research News
This article first appeared in MedPage Today (http://www.medpagetoday.com/meetingcoverage/mds/65883) by Kristina Fiore, Deputy Managing Editor, MedPage Today June 08, 2017 VANCOUVER — Two companies are working on anti-tau monoclonal antibodies for progressive supranuclear palsy (PSP), although one withdrew its phase I results just ahead of the scheduled presentation at the Movement Disorder Society meeting here. AbbVie’s ABBV-8E12 and Bristol-Myers …

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Three Urso Student Summer Fellowship Grants Awarded

| By Lucas Metherall
Categories: Research News
The Urso Summer Student Program in PSP Research supports students conducting summer research projects focused on progressive supranuclear palsy. This program seeks to encourage students at all post-secondary levels to pursue research in this field in the hope of making PSP a long-term area of research interest. Projects may be in basic, translational, clinical or …

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CurePSP-Affiliated Study Needs you!

| By Lucas Metherall
Categories: Research News
Care Where It Counts: Understanding the Needs of People with PSP and Related Disorders Goals: People with Progressive Supranuclear Palsy and related disorders like Multiple System Atrophy and Corticobasal Syndrome may have trouble accessing the healthcare that they need, which may affect their quality of life and that of their caregivers. This may be due …

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A New Understanding of How Our Brains Work

| By Lucas Metherall
Categories: Research News
Blue Brain Team Discovers a Multi-Dimensional Universe in Brain Networks Source: NEUROSCIENCE NEWS, JUNE 12, 2017 This article, appearing in Neuroscience News, reveals a new level of understanding that will force a re-think on brain science.  Using mathematics in a novel way in neuroscience, the Blue Brain Project demonstrates that the brain operates on many dimensions, not …

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CurePSP Venture Grant Goes to Dr. John Steele.

| By Lucas Metherall
Categories: Research News
Dr. John W. Steele has been awarded a CurePSP Venture Grant for a study titled “iCRISPRi in Human neurons and Glia to Elucidate Selective Turnover of Tau.” At least 13 diseases are classified as tauopathies and, collectively, this common neuropathology affects more than 5.5 million Americans, including military personnel and professional athletes who suffer from …

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Dr Troche Awarded a CurePSP Venture Grant

| By Lucas Metherall
Categories: Research News
Michelle S. Troche, PhD/CCC-SLP, has been awarded a CurePSP Venture Grant for her research project titled “Developing Treatments for Swallowing and Communication Deficits in Progressive Supranuclear Palsy (PSP).” This project won the approval of the Scientific Advisory Board for its strong scientific merits and great impact on PSP patients’ quality of life. Swallowing and communication disorders …

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Breakthrough in clearing toxic misfolded tau, in the Daily-Star, Jan 26

| By Lucas Metherall
Categories: Research News
          With $100 million from Rainwater family, brain research hits stride BY STEVE KASKOVICH, Star-Telegram, January 26 More than a year after Fort Worth billionaire Richard Rainwater lost his battle with a degenerative brain disease, his quest to find a cure is making progress. A group of top doctors and neuroscientists …

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NINDS/NIH/NIA Funding Opportunity Announcement

| By Sabrina Da Rocha
Categories: Research News
NINDS/NIH/NIA Funding Opportunity Announcement to support the genetic discovery in PSP, CBD, and related disorders. There will be a pre-application informational webinar on December 20, 2016 from 11:00-1:00 pm EDT. The webinar will provide a brief introduction to the FOA, and highlight key components and requirements of the different phases of this grant mechanism.    …

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CurePSP receives $200,000 from Nesbitt Charitable Foundation to fund two studies.

| By Lucas Metherall
Categories: Research News
CurePSP donor funds two innovative studies of PSP Nesbitt grant supports research into both care and cure   New York, NY (November 16, 2016) — CurePSP, the leading nonprofit advocacy organization focused on prime of life neurodegenerative diseases, has received a donation from the Nesbitt Charitable Fund, Houston, Texas, of $200,000 to fund two research …

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Dr. Brent Bluett Talks About Botox and Therapy For PSP Patients

| By Lucas Metherall
Categories: Research News
Ask a Doctor: Dr. Brent Bluett on PSP by Sylvia Rupani-Smith Very few patients with a rare brain disease such as Progressive Supranuclear Palsy, or PSP, have the liberty of choosing a doctor. It’s hard to find a doctor who even knows what the condition is, much less find a specialist for it. When you …

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2016 CurePSP International Research Symposium

| By Lucas Metherall
Categories: Research News
2016 CurePSP International Research Symposium             October 27, Jersey City, NJ — Starting with a networking session on the evening of Thursday, October 27, and following with a full day of speakers on Friday the 28th, the 2016 International Research Symposium has surpassed all expectations. A record 148 registrants, with some coming from countries as …

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UPenn-Led Consortium Awarded $10.8M NIH Grant to Study Genomics of Alzheimer’s Disease

| By Lucas Metherall
Categories: Research News
  UPenn-Led Consortium Awarded $10.8M NIH Grant to Study Genomics of Alzheimer’s Disease Jun 24, 2016 |a GenomeWeb staff reporter   NEW YORK (GenomeWeb) – The Perelman School of Medicine at the University of Pennsylvania announced today that it has received a grant from the National Institutes of Health’s National Institute on Aging to establish …

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CurePSP Receives Matching Grant Challenge for Genetics Research

| By Lucas Metherall
Categories: Research News, Uncategorized
Friedman family has committed up to $600,000 New York, NY (June 29, 2016) — CurePSP, the leading nonprofit advocacy organization focused on prime of life neurodegenerative diseases, today announced a matching grant challenge of up to $600,000 from the Friedman family to accelerate genetics research. An initial contribution of $250,000 toward this goal has been …

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